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Next century climate change recovery will assuredly mount up ten times withal of the World GDP.

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While it is conceivable to place an accurate monetary amount on ecosystem services, it stimulates market-based conservation and financial values.

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In mad cow disease, misfolded proteins prions punch holes in the brain causing the tissue to develop a spongy architecture eventually destroying it.

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The abnormal protein builds up in the brain, forming clumps that damage or annihilate neurons.

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The lack of healthy cells creates crevices inside the brain that produce the mental and behaviourial features of prior diseases.

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Mutations in the PRNP gene cause prion disease.

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In the title, the "new twist" refers to a feature of pathogenesis in the prion disease that consists of the conversion of a normal pre-existing molecule into a pathogenic abnormally structured form rather than replication of an agent.

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All known prion diseases, collectively called transmissible spongiform encephalopathies are untreatable and fatal.

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Prusiner was awarded the Nobel Prize in 1997 due to his studies in the detections of prion infection, its transmission track, and type the different strains.

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Some accounts of the pathogenic prion disease seem to bear out a basic tenet that any agent that increases in titer must involve replication of nucleic acid.